1998.9-2002.7 yl34511线路中心药学专业本科
2002.9–2004.7 yl34511线路中心药物化学教研室硕士研究生
2004.9-2007.7 yl34511线路中心药物化学教研室博士研究生
2016.12 – 至今 yl34511线路中心药物化学系，副教授
2012.10– 2013.10 Medicinal Chemistry Laboratory, Alcohol and Drug Abuse Research Center, McLean Hospital | Psychiatric affiliate of Harvard Medical School，访问学者
2007.7 – 2016.11 yl34511线路中心药物化学教研室，讲师
1. 阿片受体配基及其在相关疾病诊断治疗中的应用
2. 多样性化合物库的构建及其在中枢神经系统疾病治疗药物发现中的应用
1. Linghui Kong, Xuelian Shu, Siyuan Tang, Rongrong Ye, Huijiao Sun, Shuang Jiang, Zixiang Li, Jingrui Chai, Yun Fang, Yinjie Lan, Linqian Yu, Qiong Xie, Wei Fu, Yujun Wang*, Wei Li*, Zhuibai Qiu, Jinggen Liu*, and Liming Shao*. SLL-627 is a highly selective and potent κ opioid receptor (KOR) agonist with an unexpected non-reduction in locomotor activity. J Med Chem, 2022, 65(15), 10377-10392.
2. Yuanyuan Wei, Yan Ma, Songyu Yao, Linghui Kong, Xiao Liu, Jingrui Chai, Jing Chen, Wei Li*, Yujun Wang*, Liming Shao*, Jinggen Liu*. Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion. Acta Pharmacol Sin, 2022, Jun;43(6):1372-1382.
3. Qian He, Yuanyuan Wei, Xiao Liu, Rongrong Ye, Linghui Kong, Zixiang Li, Shuang Jiang, Linqian Yu, Jingrui Chai, Qiong Xie, Wei Fu, Yujun Wang*, Wei Li *, Zhuibai Qiu, Jinggen Liu*, Liming Shao *. Discovery of an m‑substituted N‑cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydro northebaine as a selective, potent, and orally active κ‑opioid receptor agonist with an improved central nervous system safety profile. J Med Chem, 2021, 64(16), 12414–12433.
4. Huoming Huang, Xueping Li, Peng Xie, Xinwei Li, XueJun Xu, Yuanyuan Qian, Congmin Yuan, Xiangguo Meng, JingRui Chai, Jing Chen, Jing Liu, Wenli Wang, Wei Li*, YuJun Wang*, Wei Fu*, Jinggen Liu. Discovery, Structure–Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3- ((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic. J Med Chem, 2021, 64(13), 9458–9483.
5. Xiao Liu, Shuang Jiang, Linghui Kong, Rongrong Ye, Li Xiao, Xuejun Xu, Qian He, Yuanyuan Wei, Zixiang Li, Huijiao Sun, Qiong Xie, Xu Xu, Yan Lu, Yujun Wang*, Wei Li*, Wei Fu, Zhuibai Qiu, Jinggen Liu*, Liming Shao*. An Exploration of the SAR Connection Between Morphinan and Arylacetamide-based κ Opioid Receptor (κOR) Agonists using the Strategy of Bridging. ACS Chem NeuroSci, 2021, 12(6), 1018-1030.
6. Bangyi Zhao#, Wei Li#, Lijie Sun, Wei Fu*. The Use of Computational Approaches in the Discovery and Mechanism Study of Opioid Analgesics. Front Chem, 2020, 8: 335.
7. Huoming Huang, Wenli Wanga, Xuejun Xu, Chen Zhu, Yujun Wang, Jinggen Liu*, Wei Li*, Wei Fu*. Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic. Eur J Med Chem, 2020, 189: 112070.
8. Li Xiao, Yujun Wang, Mumei Zhang, Weiwei Wu, Linghui Kong, Yan Ma, Xuejun Xu, Xiao Liu, Qian He, Yuanyuan Qian, Huijiao Sun, Haihao Wu, Cheng Lin, Huoming Huang, Rongrong Ye, Shuang Jiang, Rufeng Ye, Congmin Yuan, Shengyang Fang, Dengqi Xue, Xicheng Yang, Hao Chen, Yilin Zheng, Linqian Yu, Qiong Xie, Lan Zheng, Wei Fu, Wei Li*, Zhuibai Qiu, Jinggen Liu *, Liming Shao*. Discovery of a highly selective and potent kappa opioid receptor agonist from N-cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydronorthebaines with reduced central nervous system (CNS) side effects navigated by the message-address concept. J Med Chem,2019, 62(24): 11054-11070.
9. Huijiao Sun, Yuhua Wang, Congmin Yuan, Linghui Kong, Xuejun Xu, Yujun Wang, Haihao Wu, Cheng Lin, Yuanyuan Qian, Huoming Huang, Li Xiao, Xiao Liu, Qian He, Shengyang Fang, Dengqi Xue, Xicheng Yanga, Hao Chen, Yilin Zheng, Lan Zheng, Linqian Yu, Qiong Xie, Wei Fu, Wei Li*, Jinggen Liu*, Zhuibai Qiu, Liming Shao*. 7β-methyl substituent is a structural locus associated with activity cliff for nepenthone analogues. Bioorg Med Chem, 2018, 26 (14), 4254-4263.
10. Wei Li#, Jiandong Long#, Yuanyuan Qian#, Yu Long, Xuejun Xu, Yujun Wang, Qing Shen, Zuoneng Wang, Xicheng Yang, Li Xiao, Hongpeng Sun, Yulong Xu, Yiyi Chen, Qiong Xie, Yonghui Wang, Liming Shao, Jinggen Liu*, Zhuibai Qiu, Wei Fu*. The Pharmacological Heterogeneity of Nepenthone Analogs in Conferring Highly Selective and Potent kappa-Opioid Agonistic Activities. ACS Chem NeuroSci, 2017, 8 (4), 766–776.
